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Genes VII, by B. Lewin
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Oxford University Press is proud to present GENES VII--the latest edition of Benjamin Lewin's best-selling textbook. This authoritative work provides an integrated account of the structure and function of genes and incorporates all the latest research in the field.
THE MOST SIGNIFICANT REORGANIZATION TO DATE
The power of direct analysis of the genome has made a significant difference in the approach of GENES VII. In a departure from previous editions, which started with a traditional analysis of formal genetics, the new edition begins with the molecular properties of the gene itself. The text is now reorganized to begin with the concept of genes as a segment of DNA coding for protein, and then proceeds directly to the characterization of the genome in terms of its content of genes.
INTEGRATED APPROACH
GENES VII first explains the structure and function of the gene as a means to revealing the operation of the genome as a whole, and offers an integrated approach to prokaryotes and eukaryotes. The gene is considered from all aspects, including:
* Basic forms
* The numbers and relationships among genes in a genome
* Their packaging into chromosomes
* The process of gene expression from transcription through translation
* The reproduction and safeguarding of the gene structure
* Aspects of the overall circuitry through which genotype determines phenotype
STREAMLINED, FULL-COLOR DESIGN
GENES VII has been considerably restructured and reorganized to highlight the latest research and technology. It contains more than 800 full color illustrations that are extremely useful in teaching the key concepts presented in the book.
GENES VII CONTAINS NEW, GROUNDBREAKING INFORMATION ON:
* New technologies that count and compare expressed genes
* Accessory proteins (chaperones)
* The role of the proteasome
* Licensing
* Reverse translocation
* Connections between repair and recombination systems and human diseases
* Connections between the structure of chromosomal material and control of gene expression in eukaryotes
* The process of X chromosome inactivation
* Imprinting
* Control of gene expression by epigenetic changes
* The enzymatic activities that control chromatin structure and affect the regulatory process
* Archeael enzymes
* The mechanism of RNA editing in lower eukaryotes
* The role of RAG genes
* Interactions within and between pathways
* The use of protein degradation to control passage through the cell cycle
* Programmed cell death
* Telomerase and its role in carcinogenesis. And much more!
- Sales Rank: #14494945 in Books
- Published on: 2002-07-01
- Format: Import
- Number of items: 1
- Binding: Paperback
Review
...the latest edition of a very successful textbook used in many undergraduate courses...The style of teh book is very descriptive. The Times Higher Education Supplement, Friday 25th February 2000
Genes VII, published in January 2000, is latest edition of the best selling molecular biology textbook by Benjamin Lewin. ... a significant investment for many students. ...Genes VII provides readers with a comprehensive coverage of the subject in which topics are explained in detail and at length. Paul Winter, Human Genetics (2000) 107:413
`"Genes VII, published in January 2000, is latest edition of the best selling molecular biology textbook by Benjamin Lewin. ... a significant investment for many students. ...Genes VII provides readers with a comprehensive coverage of the subject in which topics are explained in detail and at length."' Paul Winter, Human Genetics (2000) 107:413
"I...the latest edition of a very successful textbook used in many undergraduate courses...The style of teh book is very descriptive. The Times Higher Education Supplement, Friday 25th February 2000
About the Author
Benjamin Lewin is editor of Cell, the premier journal in this field. He has unique access to the very best of current research and thinking.
Most helpful customer reviews
0 of 0 people found the following review helpful.
someone just looking to expand their knowledge base it has been a great deal.
By Heather Achterberg
I read some of the reviews about the book and ultimately determined it has been rejected by professors for not fitting into their current power point slides. But for me, someone just looking to expand their knowledge base it has been a great deal.
10 of 12 people found the following review helpful.
A definite improvement over Genes VI
By Dr. Lee D. Carlson
In this edition, the author dramatically departs from the last one, both in content and order of presentation, and in the author's enthusiasm. He is clearly very excited about the developments in genetics that have taken place in the last decade, and this shows up everywhere in his writing. The book would be of interest to anyone interested in genetics, whether they are students, curious laymen, or mathematicians or physicists interested in the molecular biology behind genetics. The only minus to the book is the lack of exercises, the absence of which makes the understanding of the material more time consuming. A good background in biochemistry would be very helpful in the reading of the book.
The book is a sizable one, and space does not permit a detailed review, but there are some areas in the book that stand out as being exceptionally well-written, thought-provoking, or helpful. As someone interested in bioinformatics, mathematical genetics, and mathematical modeling of metabolic processes, I read this book from the standpoint of these interests. With this in mind, some of the more interesting discussions in the book include: 1. The author constantly asks questions throughout the book, which help to clarify the issues and motivate the concepts in the book. He also points out the questions that are unanswered up to the date of publication, giving the research-oriented reader opportunities for further investigation. 2. The discussion on mutations, with the author pointing out the difference between point mutations and insertions/deletions, the role of revertants, and the occurrence of silent mutations. I wish he would have elaborated in more detail on the experiments that identified the mutations responsible for Mendel's famous wrinkled-pea mutants, i.e. the inactivation of the gene for a starch branching enzyme. 3. The discussion on the C-value paradox and the presence of large amounts of noncoding DNA in the larger genomes. This is an interesting problem for optimization theory. 4. The discussion on the mechanisms for gene reorganization. Again, this is an interesting question in optimization theory, especially the divergence between introns as a stabilizing factor that suppresses the occurrence of unequal crossing-over. The author gives examples of the effects of unequal crossing-over, such as human globin gene clusters. 5. The crossover fixation model and the time scales needed relative to mutation. 6. Satellite DNAs and their role in DNA fingerprinting. From an information theory standpoint, satellite DNAs are interesting since they are essentially long strings of DNA of low complexity. 7. The life cycle of mRNA and the neat electron micrograph illustrating beautifully the dynamics of gene expression. 8. The accuracy of translation; the author outlining the critical stages at which errors can be made. 9. The discussion on phage strategies. The dynamics of phages is very amenable to mathematical modeling. 10. They topological manipulation of DNA. Some results from the mathematical theory of knots, such as the writhing and twisting numbers, are playing a role here. 11. The discussion on transposons. The author speaks of the mobility of transposons, and the physical mechanisms employed for their transfer are elaborated on in detail. The theory of transposons has to rank as one of the most fascinating in all of genetics. 12. DNA rearrangements and their consequence, such as the creation of new genes and the switching of expression of one gene to another. The discussion on Crown gall disease is particularly interesting. 13. The discussion on the visualization of genes during transcription and the differences in the experimental results. 14. The regulation of transcription and the control mechanisms for eukaryotes. 15. RNA editing and how information is extracted from various sources. 16. The discussion on the development process in Drosophila. This chapter should begin to satisfy the reader who is curious about the molecular basis of development.
Because of its high quality, this book will no doubt continue to be one of the canonical texts in genetics to be used now and in the future to prepare students and researchers in genetics. The career opportunities opening up in bioinformatics and genetic engineering have mushroomed in recent years, a lot of this driven by the needs of drug discovery and development. In this connection, the author asks the following question in the book: "If we could read out the entire sequence of DNA comprising the genome of some organism and interpret it in terms of proteins and regulatory regions, could we then construct an organism by controlled expression of the proper genes?" One can only hope that the answer to this question will be yes, as this will create one of the most exciting of all professions in the 21st century: the genetic designer.
55 of 58 people found the following review helpful.
Thumbs down from a frustrated professor
By A Customer
Lewin's Genes series has dominated the market in Molecular Biology textbooks ... Unfortunately, its monopoly status seems to have insulated Lewin, his illustrators, and his editors from the corrective influences of a competitive market...so far.
I am in my second year of teaching from this book and I find it very frustrating. Lewin's writing style is unclear, difficult and distracting. Tangential ideas and subjects appear out of nowhere in the middle of chapters for no logical reason. As I write this, I should be preparing my lecture for Chapter 26 (Signal transduction). Why does this chapter start with a discussion of transporters? Later parts contain sentences that are almost unreadable and way too much detail about the alphabet soup of different kinases.
Although it is much better than some earlier editions, Genes VII still contains a variety of major and minor errors, including serious problems in explaining how lagging strand DNA synthesis is coordinated in the replication fork - several experts tell me that the model in figure 13.16 is simply wrong. The holoenyme does not lose one of its catalytic subunits with each cycle of Okazaki fragment synthesis. The clamp simply lets go and the clamp loader grabs the next fragment with a new clamp. I realized this semester that I had been ignoring the book and teaching what I knew from seminars.
Even when the content they describe is basically correct, figures in Genes VII can be astonishingly bad. Homologous recombination is illustrated with DNA strands that are only color coded and where the 5' and 3' ends are not labeled (Chapter 14). Unlabeled spliceosomal proteins change their color codes in the middle of the pathway - transesterification to form the lariat also seems to change U2 into U1 (Figure 22.10).
I am hoping that one of the newer competitors for Genes VII will prove to be a suitable replacement. I am examining Robert Weaver's Molecular Biology - I like what I've read so far - and should get a review copy of T.A. Brown's Genomes soon. ...Disclaimer - I have no financial interest in the success of any of these. All of them are available on Amazon.
By the way, I do have a Ph.D. in Molecular Biology. I'm not an expert in all of the material covered by Genes VII, but I was trained in labs whose work is cited in Genes VII.
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